|
KMID : 0043320090320111503
|
|
Archives of Pharmacal Research
2009 Volume.32 No. 11 p.1503 ~ p.1508
|
|
|
Inhibition of Prostaglandin E2 Production by Synthetic Wogonin Analogs
|
|
Park Hae-Il
Gurung Santosh K.
Kim Hyun-Pyo
|
|
|
Abstract
|
|
|
|
Effects of wogonin analogs on cyclooxygenase-2 (COX-2) catalyzed prostaglandin E2 production on lipopolysaccharide (LPS)-induced RAW 264.7 cells were investigated. Wogonin analogs were prepared via several different synthetic pathways. Among wogonin analogs tested, 8-halogeno and 8-nitro analogs showed strong inhibitory activities against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells. Effect of wogonin was largely dependent on structural alteration of the 8-methoxy group.
|
|
|
KEYWORD
|
|
|
Wogonin analogs, Cyclooxygenase-2 (COX-2), Prostaglandin E2 production
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|